Benzoic acid, 3-[(cyclobutylcarbonyl)amino]-4-methyl-
3-[(Cyclobutylcarbonyl)amino]-4-methylbenzoic acid
CAS: 915921-04-9
Molecular Formula: C13H15NO3
Benzoic acid, 3-[(cyclobutylcarbonyl)amino]-4-methyl- - Names and Identifiers
Benzoic acid, 3-[(cyclobutylcarbonyl)amino]-4-methyl- - Physico-chemical Properties
| Molecular Formula | C13H15NO3 |
| Molar Mass | 233.26 |
| Storage Condition | Room Temprature |
| Sensitive | Irritant |
| MDL | MFCD08569893 |
Benzoic acid, 3-[(cyclobutylcarbonyl)amino]-4-methyl- - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Hazard Class | IRRITANT |
Benzoic acid, 3-[(cyclobutylcarbonyl)amino]-4-methyl- - Introduction
3-[(Cyclobutylcarbonyl)amino]-4-methylbenzoic acid, also known as 3-[(cyclobutylformyl) amino]-4-methylbenzoic acid. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: This is a white or off-white crystalline solid.
-Solubility: It is soluble in some organic solvents, such as ethanol, dimethylformamide and dichloromethane, but has low solubility in water.
-Melting point: Its melting point is about 176-180 degrees Celsius.
Use:
-Drug intermediate: It is used as an intermediate for the synthesis of some drugs in the pharmaceutical field, such as chemotherapy drugs and anti-cancer drugs.
Preparation Method:
3-[(Cyclobutylcarbonyl)amino]-4-methylbenzoic acid can be synthesized by the following steps:
1. First, cyclobutanone reacts with p-toluenesulfonyl chloride to give 3-methyl cyclobutanone.
2. Then, 3-methyl cyclobutanone is reacted with carbamate to obtain 3-methyl -1-(methoxycarbonyl)-1-butylamine.
3. Finally, 3-methyl -1-(methoxycarbonyl)-1-butylamine is converted to 3-[(cyclobutylformyl) amino]-4-methylbenzoic acid by acid promotion.
Safety Information:
Limited safety information regarding 3-[(Cyclobutylcarbonyl)amino]-4-methylbenzoic acid. It may be irritating to the eyes, skin and respiratory tract. Appropriate safety precautions, such as wearing protective gloves, glasses and protective clothing, should be taken when handling and using the compound. If contact occurs, flush with water and seek medical help. During storage, it should be stored in a sealed container and placed in a cool, dry place.
Nature:
-Appearance: This is a white or off-white crystalline solid.
-Solubility: It is soluble in some organic solvents, such as ethanol, dimethylformamide and dichloromethane, but has low solubility in water.
-Melting point: Its melting point is about 176-180 degrees Celsius.
Use:
-Drug intermediate: It is used as an intermediate for the synthesis of some drugs in the pharmaceutical field, such as chemotherapy drugs and anti-cancer drugs.
Preparation Method:
3-[(Cyclobutylcarbonyl)amino]-4-methylbenzoic acid can be synthesized by the following steps:
1. First, cyclobutanone reacts with p-toluenesulfonyl chloride to give 3-methyl cyclobutanone.
2. Then, 3-methyl cyclobutanone is reacted with carbamate to obtain 3-methyl -1-(methoxycarbonyl)-1-butylamine.
3. Finally, 3-methyl -1-(methoxycarbonyl)-1-butylamine is converted to 3-[(cyclobutylformyl) amino]-4-methylbenzoic acid by acid promotion.
Safety Information:
Limited safety information regarding 3-[(Cyclobutylcarbonyl)amino]-4-methylbenzoic acid. It may be irritating to the eyes, skin and respiratory tract. Appropriate safety precautions, such as wearing protective gloves, glasses and protective clothing, should be taken when handling and using the compound. If contact occurs, flush with water and seek medical help. During storage, it should be stored in a sealed container and placed in a cool, dry place.
Last Update：2024-04-09 21:01:54
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